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Precision Medicine

MLL14003Thursday evenings, October 17 – November 21
7:00 to 8:30 p.m., 513 Parnassus Avenue
Course Number:  MLL14003

General Public
1 Course: $75
2 Courses: $130
3 Courses: $185

$30 Special Registration for Students with a Valid ID



What is a “disease gene”, and if you have one, why does it only change the “risk,” sometimes by tiny amounts, that you will actually get the disease? Why is the diagnosis of most diseases so far from an exact science? How could gathering information about you, and comparing it to information about many others, move us toward a new level of understanding of disease, and toward precise diagnoses, treatments and cures? UCSF leaders are at the forefront in developing a new concept, Precision Medicine, which addresses these questions. In this course, you will peer into a “precision medicine world,” and consider its impact on your health and health care. In precision medicine, data of all types– molecular, clinical, population-based– would be continuously amassed from consenting patients and citizens, then analyzed in ways that reveal unexpected correlations that drive additional molecular discoveries, new knowledge that could be applied in lab or clinic, and an understanding of health and disease so detailed as to produce precision care for you as an individual.



October 17
Overview of Precision Medicine
Keith Yamamoto, PhD
Vice Chancellor for Research, UCSF
Executive Vice Dean, School of Medicine
Professor, Cellular and Molecular Pharmacology
BIO  |  CV  |  Precision Medicine Executive Summary


October 24
Research continuum that includes patients & citizens

Martin Kampmann, PhD
Postdoctoral Fellow
Laboratory of Dr. Jonathan Weissman
Howard Hughes Medical Institute/UCSF

Melissa Paoloni, MD
Director of Advanced Clinical Trials at QuantumLeap Healthcare Collaborative
San Francisco, CA

Overview: A central question in Precision Medicine is which factors determine health and disease in a patient. For most diseases, both environmental and genetic factors play a role. We will discuss mechanisms by which genes influence disease risk and the response of an individual patient to therapy. This will then lend itself to a discussion on the clinical application of our understanding of genetics and other biology advancements with emphasis on innovative biomarker driven clinical trials in cancer. Asking how can we select the best therapies for patients and improve their outcome?


October 31

The MS Bioscreen project: Personalized Medicine from bedside to bench and back - Introduction
Pierre-Antoine Gourraud, PhD  BIO | BIO Sketch | Handout
Assistant Adjunct Professor, Department of Neurology

Creating a Knowledge Network as the Scientific Basis for Precision Medicine
Katherine Rankin, PhD

Associate Professor, UCSF Memory and Aging Center


November 7
Privacy, security, regulation and voluntary data sharing
Claire Brindis, DrPH BIO | Handout
Director, Philip R. Lee Institute for Health Policy Studies at UCSF
Professor, Department of Pediatrics and Health Policy

Dan Dohan, PhD BIO
Associate Professor, Health Policy and Social Medicine

Mini Kahlon, PhD BIO | Handout
Deputy Director and Chief Information Officer, UCSF Clinical& Translational Science Institute

Overview: Google just announced a new life sciences company to address aging; the Supreme Court recently ruled that companies can’t patent genes; An increasing number of new companies propose to work on big data in healthcare and in mobile health. How does this shifting landscape affect you? And, what are the opportunities and concerns afforded by the explosion of data about our health?  This session will provide some insights into the shifting landscape of who owns, manages and uses health-related data, empirical work on perceptions on sharing data, and highlight novel approaches to ‘freeing’ our data to accelerate research and improve health.

Privacy, security, regulation and voluntary data sharing Handout


November 14
Digital Health
Aenor Sawyer, MD  |  BIO
Assistant Clinical Professor, UCSF Department of Orthopedic Surgery


November 21
Precision Medicine for the World
Jaime Sepulveda, MD, DSc, MPH
Executive Director of Global Health Sciences at UCSF



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